ENCASE II

ENCASE-II

Randomized, two-arm, multicenter study to evaluate the safety and efficacy of LIQOSEAL® in reducing CSF leakage following elective cranial Surgery.

Primary Objective

The objective of the study is to clinically assess the safety and effectiveness of LIQOSEAL® as a means of reducing intra- as well as post-operative CSF leakage in patients undergoing elective cranial intradural surgery with a dural closure procedure to show non-inferiority compared to a control group.

Clinical Trail.gov

Click here more info!


Participating sites

USA
Albuquerque, NMUNMSC – University New Mexico Science Center
New York, NYLenox Hill Hospital NY
Dallas, TX UT Southwestern Medical Center
Cincinnati, OHUC Health
Jacksonville, FLBaptist Medical Center Jacksonville
Portland, OROHSU – Oregon Health & Science University
Rochester, AZMayo Clinic
Phoenix, AzMayo Clinic
Jacksonville, FLMayo Clinic
Europe
Utrecht, the NetherlandsUMC Utrecht
Zürich, SwitzerlandUniversitätsSpital Zürich
Tilburg, the NetherlandsETZ (Elisabeth-TweeSteden Ziekenhuis)
Mannheim, GermanyUniversity Hospital Mannheim
Besançon, FranceCHRU – Centre Hospitalier Régional Universitaire
Gent, BelgiumUZ (Universitair Ziekenhuis) Gent
Innsbruck, AustriaUniversity Hospital of Innsbruck
Torino, ItalyCittà della Salute e della Scienza

Start your LIQOSEAL training for the ENCASE II trial

In preparation of the ENCASE II trial, we are happy to introduce you to LIQOSEAL by means of an online product information and training. To start, login with your e-mailaddress and password provided to you by e-mail. The training is accessible 24/7.


Please take a look at our

Publications

Single-Arm, Open-Label, Multicenter Study to Evaluate the Safety and Performance of Dura Sealant Patch in Reducing Cerebrospinal Fluid Leakage Following Elective Cranial Surgery: The ENCASE Trial Study Protocol
https://pubmed.ncbi.nlm.nih.gov/31574157/

Effectiveness of Dural Sealants in Prevention of Cerebrospinal Fluid Leakage After Craniotomy: A Systematic Review
https://pubmed.ncbi.nlm.nih.gov/29969744/

Dural sealants for the management of cerebrospinal fluid leakage after intradural surgery: current status and future perspectives
https://pubmed.ncbi.nlm.nih.gov/31144544/

Usefulness of Sealants for Dural Closure: Evaluation in an In Vitro Model
https://pubmed.ncbi.nlm.nih.gov/29281065/

Costs of postoperative cerebrospinal fluid leakage: 1-year, retrospective analysis of 412 consecutive nontrauma cases
https://pubmed.ncbi.nlm.nih.gov/16293457/

A Pivotal Randomized Clinical Trial Evaluating the Safety and Effectiveness of a Novel Hydrogel Dural Sealant as an Adjunct to Dural Repair
https://pubmed.ncbi.nlm.nih.gov/28927211/