Watertight Dural Closure for the Reduction of CSF leakage
Cerebrospinal fluid (CSF) leakage through the ‘dura’ (the outer protective membrane surrounding the brain) is one of the most common neurosurgical complications, occurring in 4-32% of cases. Incidence rates vary depending on age, indication, location of surgery and underlying pathology. Such complications necessitate prolonged hospital stays, antibiotic treatment for meningitis, external lumbar drainage and/or reoperation. As a result, CSF leakage represents a significant patient burden, costing an estimated US $10,000 to $15,000 per patient per leakage.
To avoid CSF leakage after cranial surgery, dural closure must be watertight. Current commercially available dural sealants have not proven to significantly reduce post-operative CSF leakage compared to suturing alone. There is a critical need for more effective and easy-to-use sealants that offer prolonged dural adherence.